Concerning the problem of the background interference during the salient object detection, a key salient object detection algorithm was proposed based on filtering integration in this paper. The proposed algorithm integrated the locally guided filtering with the improved DoG (Difference of Gaussia) filtering, and made the salient object more highlighted. Then, the key points set was determined by using the saliency map, and the result of saliency detection was got by adjustment factor, which was more suitable for human visual system. The experimental results show that the proposed algorithm is superior to existing significant detection methods. And it can restrain the background interference effectively, and have higher precision and better recall rate compared with other methods, such as Local Contrast (LC), Spectral Residual (SR), Histogram-based Contrast (HC), Region Contrast (RC) and Frequency-Tuned (FT).